Research is focused on the design of Molecules for biomedical, agricultural and environmental applications. The improvement of Synthetic Methods granting the sustainable chemistry concept is a common factor to all synthetic procedures.
Several classes of molecular frameworks such as hydroxypyridinones and porphyrins, are functionalized with chemical groups to produce molecules whose physicochemical properties are fine-tuned according to the application in view. Examples are fluorescent chelators to monitor and sensing metal ions in body fluids and natural waters, anticancer, antimalarial, antimicrobial and novel anti-inflammatory drug candidates.
Hydroxypyridinones and porphyrins possess excellent chelating properties and the group synthesizes a variety of metal ion complexes that also find application in the biomedical and agriculture fields.
The characterization of the molecules produced is performed in the solid state and in solution, using several spectroscopic methods. Speciation studies in aqueous solution are particularly important for all the fields of application.
Synthesis and characterization of two fluorescent isophthalate rosamines: from solution to immobilization in solid substrates, Carla Queirós, Andreia Leite, Luís Cunha-Silva, Baltazar de Castro, Maria Rangel, Ahmad Sousaraei, Juan Cabanillas-Gonzalez, Francisco Gámez, Estefanía Jamardo, Alejandro P. Vargas, Francisco G. Moscoso, Tânia Lopes-Costa, José M. Pedrosa, Ana M. G. Silva, Dyes and Pigments, 2018, 157, 405-414.; https://dx.doi.org/10.1016/j.dyepig.2018.05.005
Synthesis and coordination studies of 5-(4′-carboxyphenyl)-10,15,20-tris(pentafluorophenyl)porphyrin and its pyrrolidine-fused chlorin derivative José Almeida, André M. N. Silva, Susana L. H. Rebelo, Luís Cunha-Silva, Maria Rangel, Baltazar de Castro, Andreia Leite and Ana M. G. Silva, New. J. Chem., 2018, 42, 8169-8179.; https://dx.doi.org/10.1039/C7NJ05165D
1,3-Dipolar cycloadditions with meso-tetraarylchlorins – site selectivity and mixed bisadducts, J. Almeida, A. Aguiar, A. Leite, A. M. N. Silva, L. Cunha-Silva, B. de Castro, M. Rangel, G. Barone, A. Tomé and A. M.G. Silva Organic Chemistry Frontiers, 2017,4, 534-544.; http://dx.doi.org/10.1039/C6QO00771F
Isoxazolidine-fused meso-tetraarylchlorins as key tools for the synthesis of mono- and bis-annulated chlorins, Silva, Ana; Aguiar, António; Leite, Andreia; Silva, André; Tome, Augusto; Cunha-Silva, L.; de Castro, Baltazar; Rangel, Maria, Organic Biomolecular Chemistry, 2015,13, 7131-7135.; http://dx.doi.org/10.1039/C5OB00800J
Synthesis and spectroscopic characterization of a new tripodal hexadentate iron chelator incorporating catechol units, Carla Queirós, Andreia Leite, Ana M. G. Silva, Paula Gameiro, Baltazar de Castro, Maria Rangel, Polyhedron, 2015, 87, 1; http://dx.doi.org/10.1016/j.poly.2014.10.003
The influence of the amide linkage in the iron(III)-binding properties of catechol modified rosamine derivatives, Carla Queirós, Andreia Leite, Maria G. M. Couto, Luís Cunha-Silva, Giampaolo Barone, Baltazar de Castro, Maria Rangel, André M. N. Silva,* and Ana M. G. Silva*, Chemistry - A European Journal, 2015, 21, 15692-15704.; http://dx.doi.org/10.1002/chem.201502093