Rhodamines and their analogues (rosamines) are an important class of fluorescent dyes with high molar absorptivity and intense fluorescence spectrum in the visible region. Its successful applications as fluorescent sensors and bioimaging probes have paved the way to explore new strategies to create high-performance molecules, mainly through structural modifications of the xanthenic ring.

We took profit of our experience in the design of fluorescent rhodamine chelators to be used within the cell and develop to metal ion sensors which give a specific response to different metal ions in different types of matrices. We strategically couple chelators to rhodamines (and other fluorescent dyes) in order to produce molecules that exhibit ‘OFF/ON’ or ‘ON/OFF’ response. More recently we are interested in the preparation of new organic-inorganic hybrid materials that allow the simultaneous detection, quantification and removal of target metal ions in different matrices.


Functionalization of rhodamine platforms with 3-hydroxy-4-pyridinone chelating units and its fluorescence behavior towards Fe(III), Carla Queirós, Sílvia Vinhas, Jéssica Oliveira, Andreia Leite, Ana M. G. Silva and M. Rangel, Molecules 2022, 27, 1567. https://doi.org/10.3390/molecules27051567


Synthesis of catechol derived rosamine dyes and their reactivity towards biogenic amines, Filipe Monteiro-Silva, Carla Queirós, Andreia Leite, María Teresa Rodríguez, María José Rojo, Tomás Torroba, Rui C. Martins, Ana M. G. Silva and Maria Rangel, Molecules 2021, 26, 5082. https://doi.org/10.3390/molecules26165082.


Synthesis of pyridyl and N-methylpyridinium analogues of rosamines. Relevance of solvent and charge on their photophysical properties, Andreia Leite, Luís Cunha-Silva, Daniel Silva, Ana I. M. C. Lobo Ferreira, Luís M. N. B. F. Santos, Inês C. S. Cardoso, Vera L. M. Silva, Maria Rangel and Ana M. G. Silva, Chem. Eur. J. 2019, 25, 15073-15082. https://doi.org/10.1002/chem.201903313.


Synthesis and characterization of two fluorescent isophthalate rosamines: from solution to immobilization in solid substrates, Carla Queirós, Andreia Leite, Luís Cunha-Silva, Baltazar de Castro, Maria Rangel, Ahmad Sousaraei, Juan Cabanillas-Gonzalez, Francisco Gámez, Estefanía Jamardo, Alejandro P. Vargas, Francisco G. Moscoso, Tânia Lopes-Costa, José M. Pedrosa and Ana M. G. Silva, Dyes Pigm. 2018, 157, 405 414. https://doi.org/10.1016/j.dyepig.2018.05.005.


The influence of the amide linkage in the iron(III)-binding properties of catechol modified rosamine derivatives, Carla Queirós, Andreia Leite, Maria G. M. Couto, Luís Cunha-Silva, Giampaolo Barone, Baltazar de Castro, Maria Rangel, André M. N. Silva and Ana M. G. Silva Chem. Eur. J. 2015, 21, 15692–15704. http://dx.doi.org/10.1002/chem.201502093.