Spectroscopy is an essential tool to address problems in the coordination chemistry and bioinorganic chemistry fields and the group integrates members that have strong expertise on EPR and NMR Spectroscopy, X-ray Absorption Spectroscopy, Fluorescence Spectroscopy and Mass Spectrometry. The latter methods have been thoroughly used to study speciation of chelators and metal-chelates in solution and to study their partition and permeation properties throughout biological membranes.
EPR and 51V NMR studies of prospective anti-diabetic bis(3-hydroxy-4-pyridinonato) oxidovanadium(IV) complexes in aqueous solution and liposome suspensions, S. Ferreira, A. Leite, T. Moniz, M. Andrade, L. Amaral, B. de Castro and M. Rangel New. J. Chem., 2018, 42, 8088-8097; https://dx.doi.org/10.1039/C7NJ04678B
NMR study of the interaction of fluorescent 3-hydroxy-4-pyridinone chelators with DMPC liposomes, Tânia Moniz, Baltazar de Castro, Maria Rangel, Galya Ivanova, Physical Chemistry Chemical Physics, 2016, 18, 5027-5033; http://dx.doi.org/10.1039/c5cp05273d
Distinctive EPR signals provide understanding of the affinity of bis-(3-hydroxy-4-pyridinonato) copper (II) complexes for hydrophobic environments, Maria Rangel, Andreia Leite, André M. N. Silva, Tânia Moniz, Ana Nunes, M. João Amorim, Carla Queirós, Luís Cunha-Silva, Paula Gameiro, and John Burgess, Dalton Transactions, 2014, 43, 9722-97-31; http://dx.doi.org/10.1039/C4DT00642A.
EPR and XANES Studies of the Anaerobic Photolysis of iso-propilpyridinecobaloxime: elucidation of the reactivity of the Co(II) primary product, Maria Rangel, Andreia Leite, André Silva, Baltazar de Castro, Walkiria Schlindwein and Loretta Murphy, J. Organometallic Chem., 2014, 760, 11-18. http://dx.doi.org/10.1016/j.jorganchem.2014.01.033
Relevant interactions of antimicrobial iron chelators and membrane models revealed by NMR and Molecular Dynamics simulations, João T.S. Coimbra, Tânia Moniz, Natércia F. Brás, Galya Ivanova, Pedro A. Fernandes, Maria J. Ramos and Maria Rangel, Journal of Physical Chemistry B, 2014, 118, 14590−14601. http://dx.doi.org/10.1021/jp509491p
Nickel(II) and cobalt(II) 3-hydroxy-4-pyridinone complexes: synthesis, characterization and speciation studies in aqueous solution, Carla Queiros, M. João Amorim, Andreia Leite, Monica Ferreira, Paula Gameiro, Baltazar de Castro, Krzysztof Biernacki, Alexandre Magalhães, John Burgess, Maria Rangel, Eur. J. Inorg. Chem., 2011, 131-140; http://dx.doi.org/10.1002/ejic.201000849
Spectroscopic and potentiometric characterization of oxovanadium(IV) complexes formed by 3-hydroxy-4-pyridinones. Rationalization of the influence of basicity and electronic structure of the ligand on of the ligand on the properties of VIVO species in aqueous solution, Maria Rangel, Andreia Leite, M. João Amorim, Eugenio Garriba, Giovanni Micera, Elzbieta Lodyga-Chruscinska, Inorg. Chem., 2006, 45, 8086-8097; http://dx.doi.org/10.1021/ic0605571
New Lipophilic 3-hydroxy-4-pyridinone iron(III) complexes: synthesis and EXAFS structural characterization, Walkiria Schlindwein, Emma Waltham, John Burgess, Norman Binsted, Ana Nunes, Andreia Leite and Maria Rangel, Dalton Trans., 2006, 1313 – 1321; http://dx.doi.org/10.1039/b509671e