PhD in Chemistry, 2011, Faculty of Sciences, University of Porto
Thesis: Design de ligandos quelantes multifuncionalizados derivados de 3,4-hidroxipiridinonas.
Area of scientific activity
Over the past fourteen years has collaborated in the Inorganic and Bioinorganic Chemistry group from the Faculty of Sciences, University of Porto in several projects: "Synthesis, structure , precipitation, solution speciation and biological studies of vanadium compounds with potential for treating diabetes", "Study of structural determinant factors in the reactivity of the photolysis products of compounds B12 model system", "Design of macromolecular chelating iron and intercellular evaluation of its antimicrobial activity" and "Protection against the toxicity of iron by the immune system: cells, proteins and mechanisms" .
As a member of the group has particular interest in the design of new molecules with potential therapeutic application and the use of spectroscopic techniques to access their behavior in solution.
Domain of specialization
Specialized in the design and solution study of new molecules with potential application in biological systems.
Experience in synthesis and spectroscopic techniques acquired in the workgroup and in EXAFS and XANES acquired during a scholarship in England at the Daresbury Laboratory.
In 2003 attended a Spectroscopy and Spectrometry Course at the Faculty of Pharmacy, University of Porto, in which the themes UV / VIS, fluorescence, FTIR, NMR, EPR and X-rays were approached from a theoretical point of view and application to biological systems.
In 2004 attended to the Nuclear Magnetic Resonance Spectroscopy course, organized by the Faculty of Pharmacy, University of Porto.
In 2007 participated in the VII Course of the Portuguese Society of Biophysics, on "Biospectroscopy and Imaging".
In 2008, participated in the Monographic Course:" Nuclear Magnetic Resonance: from theory to practice", organized by the Faculty of Science and Technology, University of New Lisbon (UNL).
Present research interest
Postdoctoral of a FCT (Fundação para a Ciência e a Tecnologia) grant.
The present research interests are centered in Biophysical and Bioinorganic Chemistry, in particular in the design of new turn-on sensors for metal ions namely iron, copper, zinc and vanadium.
The study of metal ion complexes and their administration with a potential therapeutic effect by regulation of metal ions levels in living organisms is another research interest.
During the developed work as a scholar and PhD student she acquired experience in synthesis, particularly in the implementation of greener methods. During this time as also deepened the knowledge in different spectroscopies, in particular fluorescence, NMR and EPR, as well as its application in biological studies concerning the partition and localization of the new molecules in the membranes.
Rangel, M., A. Leite, A. M. Silva, T. Moniz, A. Nunes, M. J. Amorim, C. Queiros, L. Cunha-Silva, P. Gameiro and J. Burgess, Distinctive EPR signals provide an understanding of the affinity of bis-(3-hydroxy-4-pyridinonato) copper(II) complexes for hydrophobic environments, Dalton Trans 2014, 43, 9722-9731.
Leite, A., A. M. Silva, L. Cunha-Silva, B. de Castro, P. Gameiro and M. Rangel, Discrimination of fluorescence light-up effects induced by pH and metal ion chelation on a spirocyclic derivative of rhodamine B, Dalton Trans, 2013, 42, 6110-6118.
Leite, A., A. M. G. Silva, A. Nunes, M. Andrade, C. Sousa, L. Cunha-Silva, P. Gameiro, B. de Castro and M. Rangel, Novel tetradentate chelators derived from 3-hydroxy-4-pyridinone units: synthesis, characterization and aqueous solution properties, Tetrahedron, 2011, 67, 4009-4016.
Silva, A. M. G., A. Leite, M. Andrade, P. Gameiro, P. Brandão, V. Felix, B. de Castro and M. Rangel, Microwave-assisted synthesis of 3-hydroxy-4-pyridinone/naphthalene conjugates. Structural characterization and selection of a fluorescent ion sensor, Tetrahedron, 2010, 66, 8544-8550.
Rangel, M., M. J. Amorim, A. Nunes, A. Leite, E. Pereira, B. de Castro, C. Sousa, Y. Yoshikawa and H. Sakurai, Novel 3-hydroxy-4-pyridinonato oxidovanadium(IV) complexes to investigate structure/activity relationships, J Inorg Biochem, 2009, 103, 496-502.