>Maria Rangel

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Academic qualifications (degree, university, dates e classification)
Degree in Chemistry, 1973/78, 16/20, University of Porto Ph.D. Biomedical Sciences, 1989, University of Porto
Professor Agregado, Biomedical Sciences, 2011, University of Porto

Maria Rangel is an Associate Professor at Instituto de Ciências Biomédicas de Abel Salazar of University of Porto. She has been responsible for courses on Chemical Biology, Thermodynamics, Biophysical Chemistry and Structural Analysis. She has supervised the work of several Post-Doctoral, Ph.D., M.Sc. and Project Students.
At present she is Co-Director of the Integrated Master Course of Bioengineering.

Researcher at LAQV-REQUIMTE
Member of the Scientific and Technical Board of REQUIMTE
Scientist in charge of the NMR and EPR Laboratories of University of Porto

Maria Rangel is a Bioinorganic Chemist whose domains of specialization are Inorganic and Physical Chemistry. She has large experience in the fields of Coordination Chemistry and Spectroscopy. Her research interests are focused in the role of metal ions in living organisms and, in the recent years she has worked on the design of Iron chelators for: (a) novel strategies to fight Infection through Fe deprivation; (b) treatment of Fe Overload and (c) Fe Sensing. Her interest in Iron Biology has been extended to plant nutrition and she is currently developing projects that aim the understanding of mineral nutrition processes and the design of Fe-chelates to address agricultural problems related with Fe deficiency. The development of insulin-like vanadium and zinc complexes and the study of B12 model compounds are two topics that have also been explored in previous years.

Maria Rangel has been Principal Investigator of several multidisciplinary projects and has a considerable experience in coordinating teams developing research on the interfaces of chemistry and biology.

 

     >selected publications

 

A.M.N. Silva, T. Moniz, B. de Castro and M. Rangel*, Human transferrin: An inorganic biochemistry perspective, Coordination Chemistry Reviews, 2021, 449, 214186. https://doi.org/10.1016/j.ccr.2021.214186.

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M. Rangel*, T. Moniz, A.M.N. Silva and A. Leite, Tuning the anti (Myco)bacterial activity of 3-hydroxy-4-pyridinone chelators through fluorophores, Pharmaceuticals, 2018, 11, 110. https://doi.org/10.3390/ph11040110.

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J. Burgess and M. Rangel, Hydroxypyranones, hydroxypyridinones, and their complexes, Advances in Inorganic Chemistry, 2008, 60, 167-243. http://dx.doi.org/10.1016/S0898-8838(08)00005-6.

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C.S. Santos, A. Leite, S. Vinhas, S. Ferreira, T. Moniz, M.W. Vasconcelos and M. Rangel*, A combined physiological and biophysical approach to understand the ligand-dependent efficiency of 3-hydroxy-4-pyridinone Fe-chelates, Plant Direct, 2020, 4, e00256. https://doi.org/10.1002/pld3.256.

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M. Rangel*, A. Leite, A.M.N. Silva, T. Moniz, A. Nunes, M.J. Amorim, C. Queiros, L. Cunha-Silva, P. Gameiro and J. Burgess, Distinctive EPR signals provide an understanding of the affinity of bis-(3-hydroxy-4-pyridinonato) copper(ii) complexes for hydrophobic environments, Dalton Transactions, 2014, 43, 9722-9731. http://dx.doi.org/10.1039/C4DT00642A.

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T. Moniz, L. Cunha-Silva, R.B.R. Mesquita, J.L.A. Miranda, A.M.N. Silva, A.M.G. Silva, A.O.S.S. Rangel, B. de Castro and M. Rangel*, New hydrophilic 3-hydroxy-4-pyridinone chelators with ether-derived substituents: Synthesis and evaluation of analytical performance in the determination of iron in waters, Polyhedron, 2019, 160, 145-156.  https://dx.doi.org/10.1016/j.poly.2018.12.005.

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C. Queirós, A.M.G. Silva, S.C. Lopes, G. Ivanova, P. Gameiro and M. Rangel*, A novel fluorescein-based dye containing a catechol chelating unit to sense iron(III), Dyes and Pigments, 2012, 93, 1447-1455.  https://dx.doi.org/10.1016/j.dyepig.2011.10.010.

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T. Moniz, M.J. Amorim, R. Ferreira, A. Nunes, A. Silva, C. Queirós, A. Leite, P. Gameiro, B. Sarmento, F. Remião, Y. Yoshikawa, H. Sakurai and M. Rangel, Investigation of the insulin-like properties of zinc(II) complexes of 3-hydroxy-4-pyridinones: Identification of a compound with glucose lowering effect in STZ-induced type I diabetic animals, Journal of Inorganic Biochemistry, 2011, 105, 1675-1682. http://dx.doi.org/10.1016/j.jinorgbio.2011.09.005

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M. Rangel, A. Leite, M. João Amorim, E. Garribba, G. Micera and E. Lodyga-Chruscinska, Spectroscopic and Potentiometric Characterization of Oxovanadium(IV) Complexes Formed by 3-Hydroxy-4-Pyridinones. Rationalization of the Influence of Basicity and Electronic Structure of the Ligand on the Properties of V(IV)O Species in Aqueous Solution, Inorganic Chemistry, 2006, 45, 8086-8097. http://dx.doi.org/10.1021/ic0605571.

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M. Rangel*, A. Leite, A. Silva, B. de Castro, W. Schlindwein and L. Murphy, EPR and XANES studies of anaerobic photolysis of iso-propilpyridinecobaloxime: Elucidation of the reactivity of the Co(II) primary product, Journal of Organometallic Chemistry, 2014, 760, 11-18. http://dx.doi.org/10.1016/j.jorganchem.2014.01.033.