>Maria Rangel

Academic qualifications (degree, university, dates e classification)
Degree in Chemistry, 1973/78, 16/20, University of Porto Ph.D. Biomedical Sciences, 1989, University of Porto
Professor Agregado, Biomedical Sciences, 2011, University of Porto

Maria Rangel is an Associate Professor at Instituto de Ciências Biomédicas de Abel Salazar of University of Porto. She has been responsible for courses on Chemical Biology, Thermodynamics, Biophysical Chemistry and Structural Analysis. She has supervised the work of several Post-Doctoral, Ph.D., M.Sc. and Project Students.
At present she is Co-Director of the Integrated Master Course of Bioengineering.

Researcher at LAQV-REQUIMTE
Member of the Scientific and Technical Board of REQUIMTE
Scientist in charge of the NMR and EPR Laboratories of University of Porto

Maria Rangel is a Bioinorganic Chemist whose domains of specialization are Inorganic and Physical Chemistry. She has large experience in the fields of Coordination Chemistry and Spectroscopy. Her research interests are focused in the role of metal ions in living organisms and, in the recent years she has worked on the design of Iron chelators for: (a) novel strategies to fight Infection through Fe deprivation; (b) treatment of Fe Overload and (c) Fe Sensing. Her interest in Iron Biology has been extended to plant nutrition and she is currently developing projects that aim the understanding of mineral nutrition processes and the design of Fe-chelates to address agricultural problems related with Fe deficiency. The development of insulin-like vanadium and zinc complexes and the study of B12 model compounds are two topics that have also been explored in previous years.

Maria Rangel has been Principal Investigator of several multidisciplinary projects and has a considerable experience in coordinating teams developing research on the interfaces of chemistry and biology.


     >selected publications

“Effect of tris(3-hydroxy-4-pyridinonate) iron(III) complexes on iron uptake and storage in soybean (Glycine max L.) Santos, Carla; Carvalho, Susana; Leite, Andreia; Moniz, Tânia; Roriz, Mariana; Rangel, Antonio; Rangel, Maria; Vasconcelos, Marta, Plant Physiology and Biochemistry, 2016, 106, 91-100.

“NMR study of the interaction of fluorescent 3-hydroxy-4-pyridinone chelators with DMPC liposomes, Tânia Moniz, Baltazar de Castro, Maria Rangel, Galya Ivanova, Physical Chemistry Chemical Physics, 2016, 18, 5027-5033.

Use of an hexadentate 3,4-hydroxypiridinone chelator as a novel chromogenic agent for the sequential injection iron speciation in waters”, Joana L Miranda, Ana Nunes, Maria Rangel, António Rangel, Raquel B. R. Mesquita, Talanta, 2016, 148, 633-640.

“Synthesis and structural characterization, by spectroscopic and computational methods, of two fluorescent 3-hydroxy-4-pyridinone chelators bearing sulphorhodamine B and naphthalene, T. Moniz, J.T. S. Coimbra, N. F. Brás, L. Cunha-Silva, M. J. Ramos, P. A. Fernandes, B. de Castro and M. Rangel, RSC Adv., 2016, 6, 4200-4211.

“Antimycobacterial activity of rhodamine 3,4-HPO iron chelators against Mycobacterium avium: analysis of the contribution of functional groups and of chelator´s combination with ethambutol”, Tânia Moniz, Daniel Silva, Tânia Silva, Maria Salomé Gomes and Maria Rangel, Med. Chem. Comm., 2015, 6, 2194-2203

“Synthesis and characterization of a 3-hydroxy-4-pyridinone chelator functionalized with a polyethylene glycol (PEG) chain aimed at sequential injection determination of iron in natural waters”, Raquel B. R. Mesquita, Tânia Moniz, Joana L. A. Miranda, Vânia Gomes, André M. N. Silva, J. E. Rodriguez-Borges, António O. S. S. Rangel, Maria Rangel, Polyhedron, 2015, 101, 171-178.

“Relevant interactions of antimicrobial iron chelators and membrane models revealed by NMR and Molecular Dynamics simulations”, João T.S. Coimbra, Tânia Moniz, Natércia F. Brás, Galya Ivanova, Pedro A. Fernandes, Maria J. Ramos and Maria Rangel, Journal of Physical Chemistry B, 2014, 118, 14590−14601.

“EPR and XANES Studies of the Anaerobic Photolysis of iso-propilpyridinecobaloxime: elucidation of the reactivity of the Co(II) primary product”, Maria Rangel, Andreia Leite, André Silva, Baltazar de Castro, Walkiria Schlindwein and Loretta Murphy, J. Organometallic Chem., 2014, 760, 11-18.

“Distinctive EPR signals provide understanding of the affinity of bis-(3-hydroxy-4-pyridinonato) copper (II) complexes for hydrophobic environments”, Maria Rangel, Andreia Leite, André M. N. Silva, Tânia Moniz, Ana Nunes, M. João Amorim, Carla Queirós, Luís Cunha-Silva, Paula Gameiro, and John Burgess, Dalton Transactions, 2014, 43, 9722-97-31.

"Rhodamine labelling of 3-hydroxy-4-pyridinone iron chelators is an important contribution to target Mycobacterium avium infection", Tânia Moniz, Ana Nunes, Ana M. G. Silva, Carla Queirós, Galya Ivanova, M. S. Gomes and Maria Rangel, J. Inorg. Biochem., 2013, 121, 156-166.

"Discrimination of fluorescence light-up effects induced by pH and metal ion chelation on a spirocyclic derivative of rhodamine B", Andreia Leite, Ana M. G. Silva, Luís Cunha-Silva, Baltazar de Castro, Paula Gameiro and Maria Rangel, Dalton Trans., 2013, 42, 6110-6118.

“Investigation of the insulin-enhancing properties of Zinc(II) 3-hydroxy-4-pyridinone complexes: identification of a new compound with a hypoglycemic effect in type I-like diabetic animals”, Tânia Moniz, M. João Amorim, Rita Ferreira, Ana Nunes, Ana Silva, Carla Queirós, Andreia Leite, Paula Gameiro, Bruno Sarmento, Fernando Remião, Yutaka Yoshikawa, Hiromu Sakurai and Maria Rangel, J. Inorg. Biochem., 2011, 105, 1675–1682,

“Nickel(II) and cobalt(II) 3-hydroxy-4-pyridinone complexes: synthesis, characterization and speciation studies in aqueous solution”, Carla Queiros, M. João Amorim, Andreia Leite, Monica Ferreira, Paula Gameiro, Baltazar de Castro, Krzysztof Biernacki, Alexandre Magalhães, John Burgess, Maria Rangel, Eur. J. Inorg. Chem., 2011, 131-140.

“Fluorescent 3-hydroxy-4-pyridinone hexadentate iron chelators: intracellular distribution and the relevance to anti-mycobacterial properties” Ana Nunes, Maria Podinovskaia, Andreia Leite, Paula Gameiro, Tao Zhou, Yongmin Ma, Xiaole Kong, Ulrich E. Schaible, Robert C. Hider and Maria Rangel, J. Biol. Inorg. Chem., 2010, 15, 861-877.

"Identification of a new hexadentate iron chelator capable of restricting the intramacrophagic growth of Mycobacterium avium", Fernandes, Sofia. S. Fernandes, Ana Nunes, Ana R. Gomes, Baltazar Castro, Robert C. Hider, Maria Rangel, Rui Appelberg, Maria Salomé Gomes, Microbes and Infection, 2010, 12, 287-294.

"Novel 3-hydroxy-4-pyridinonato oxidovanadium(IV) complexes to investigate structure/activity relationships", Maria Rangel, M. João Amorim, Ana Nunes, Andreia Leite, Eulália Pereira Baltazar de Castro, Carla Sousa, Yutaka Yoshikawa and Hiromu Sakurai, J. Inorg. Biochem, 2009, 103, 496-502.

"Hydroxypyranones, hydroxypyridinones and their complexes", John Burgess and Maria Rangel, Advances in Inorganic Chemistry, 2008, 60, 167-243.

"EPR study of the photolysis of methyl- and adenosyl-cobinamides in the presence of phosphine and pyridine bases. Evidence for the need of a judicious choice of irradiation temperature and solvent to assess ligand binding", João Gomes, Baltazar de Castro and Maria Rangel, Organometallics, 2008, 27, 2536.

Spectroscopic and potentiometric characterization of oxovanadium(IV) complexes formed by 3-hydroxy-4-pyridinones. Rationalization of the influence of basicity and electronic structure of the ligand on of the ligand on the properties of VIVO species in aqueous solution ”, Maria Rangel, Andreia Leite, M. João Amorim, Eugenio Garriba, Giovanni Micera, Elzbieta Lodyga-Chruscinska, Inorg. Chem., 2006, 45, 8086-8097.

“New Lipophilic 3-hydroxy-4-pyridinone iron(III) complexes: synthesis and EXAFS structural characterization”, Walkiria Schlindwein, Emma Waltham, John Burgess, Norman Binsted, Ana Nunes, Andreia Leite and Maria Rangel, Dalton Trans., 2006, 1313 - 1321.

“Pyridinone oxovanadium(IV) complexes: a new class of insulin mimetic compounds”, Maria Rangel, Transition Met. Chem., 2001, 26, 219-223.

“Photolysis primary products of alkylcobaloximes controlled by the cobalt-carbon bond strength”. Maria Rangel, Teresa Arcos and Baltazar de Castro, Organometallics, 1999, 18, 3451-3456.

“Synthesis and characterization of 3-hydroxy-4-pyridinone oxovanadium(IV) complexes”. J. Burgess, B. de Castro, C. Oliveira , M. Rangel and W. Schlindwein, Polyhedron, 1997, 16, 789.

“An ESR spectral study of the cobalt(II) species formed after room temperature photolysis of aquo-sec-butylbis(dimethylglyoximato)cobalt(III) with N-donor bases”. Teresa Arcos, Baltazar de Castro, M.J. Ferreira , M. Rangel and J.B. Raynor, J.Chem. Soc., Dalton Trans., 1994, 369-377.

“EPR characterization of the photolysis products of some alkylcobaloximes with symmetric phosphines and phosphites. Factors that stabilize the cobalt homolysis fragments”. B de Castro, J. Pereira and M. Rangel, Organometallics, 1991, 10, 3848-3855.

“An ESR spectral study of bis(dimethylglyoximato)cobalt(II) with some phosphine and phosphite adducts”. Baltazar de Castro, M. Rangel and J.B. Raynor, J.Chem. Soc., Dalton Trans., 1990, 3311-3318.