email: ana.silva@fc.up.pt

Tel: +351 22 0402 585

     >Ana Margarida Silva

Area of scientific activity

  • Research interests in organic chemistry, particularly in the synthesis of porphyrinic macrocycles and analogues.

  • Synthesis of chelating ligands and their coordination complexes.

  • Design of colorimetric and fluorescent ligands with clinical and environmental applications.

  • Implementation of advanced synthetic methodologies based on the “green chemistry” concepts, including the use of microwave-assisted organic chemistry and the development of new heating processes based on Ohmic heating for perform organic synthesis in water.


Domain of specialization

organic chemistry, inorganic chemistry


Present research interest

  • Synthesis and characterization of new functionalized porphyrins.

  • Design of multi-functionalized molecules for applications in medicinal and environmental Chemistry.

  • Preparation of functional building blocks.

  • Advanced heating methodologies for chemical synthesis.

  • Design of new ligands for metal-organic frameworks (MOFs).



     >selected publications

[1]  Queirós, C., Leite, A., Cunha-Silva, L., de Castro, B., Rangel, M., Sousaraei, A., Cabanillas-Gonzalez, J., Gámez, F., Jamardo, E., Vargas, A.P., Moscoso, F.G., Lopes-Costa, T., Pedrosa, J.M., Silva, A.M.G., Synthesis and characterization of two fluorescent isophthalate rosamines: from solution to immobilization in solid substrates, Dyes Pigm. 2018, 157, 405-414.

[2]  Almeida, J., Aguiar, A., Leite, A., Silva, A.M.N., Cunha-Silva, L., de Castro, B., Rangel, M., Barone, G., Tomé, A.C., Silva, A.M.G., 1,3-Dipolar cycloadditions with meso-tetraarylchlorins – site selectivity and mixed bisadducts, Org. Chem. Front., 2017, 4, 534 544. http://dx.doi.org/10.1039/C6QO00771F.


[3]  Queirós, C., Leite, A., Couto, M.G.M., Cunha-Silva, L., Barone, G., de Castro, B., Rangel, M., Silva, A.M.N., Silva, A.M.G., The influence of the amide linkage in the iron(III)-binding properties of catechol modified rosamine derivatives, Chem. Eur. J., 2015, 21, 15692–15704.

[4]  Aguiar, A., Leite, A., Silva, A.M.N., Tomé, A.C., Cunha-Silva, L., de Castro, B., Rangel, M., Silva, A.M.G., Isoxazolidine-fused meso-tetraarylchlorins as key tools for the synthesis of mono- and bis-annulated chlorins, Org. Biomol. Chem., 2015, 13, 7131-7135.

[5]  Pinto, J., Silva, V.L.M., Silva, A.M.G., Silva, A.M.S., Costa, J.C.S., Santos, L.M.N.B.F., Enes, R., Cavaleiro, J.A.S., Vicente, A.A.M.O.S., Teixeira, J.A.C., Ohmic heating as a new efficient process for organic synthesis in water, Green Chem., 2013, 15, 970–975.


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