Tel: +351 22 0402 585

     >Ana Margarida Silva

Area of scientific activity

  • Research interests in organic chemistry, particularly in the synthesis of porphyrinic macrocycles and analogues.

  • Synthesis of chelating ligands and their coordination complexes.

  • Design of colorimetric and fluorescent ligands with clinical and environmental applications.

  • Implementation of advanced synthetic methodologies based on the “green chemistry” concepts, including the use of microwave-assisted organic chemistry and the development of new heating processes based on Ohmic heating for perform organic synthesis in water.


Domain of specialization

organic chemistry, inorganic chemistry


Present research interest

  • Synthesis and characterization of new functionalized porphyrins.

  • Design of multi-functionalized molecules for applications in medicinal and environmental Chemistry.

  • Preparation of functional building blocks.

  • Advanced heating methodologies for chemical synthesis.

  • Design of new ligands for metal-organic frameworks (MOFs).



     >selected publications

[1] Leite, A., Cunha-Silva, L., Silva, D., Lobo Ferreira, A. I. M. C., Santos, L. M. N. B. F., Cardoso, I. C. S., Silva, V. L. M., Rangel, M., Silva, A. M. G., Synthesis of pyridyl and N-methylpyridinium analogues of rosamines. Relevance of solvent and charge on their photophysical properties, Chem. Eur. J. 2019, 25, 15073-15082.

[2] Almeida, J., Fortună, M. E., Pricop, L., Lobiuc, A., Leite, A., Silva, A. M. N., Monteiro, R. P., Rangel, M., Harabagiu, V., Silva, A. M. G., (Aminophenyl)porphyrins as precursors for the synthesis of porphyrin-modified siloxanes, J. Porphyrins Phthalocyanines 2019, 23, 1001–1012.

[3] Queirós, C., Leite, A., Cunha-Silva, L., de Castro, B., Rangel, M., Sousaraei, A., Cabanillas-Gonzalez, J., Gámez, F., Jamardo, E., Vargas, A.P., Moscoso, F.G., Lopes-Costa, T., Pedrosa, J.M., Silva, A.M.G., Synthesis and characterization of two fluorescent isophthalate rosamines: from solution to immobilization in solid substrates, Dyes Pigm. 2018, 157, 405-414.

[4] Almeida, J., Silva, A. M. N., Rebelo, S. L. H., Cunha-Silva, L., Rangel,M., de Castro, B., Leite, A., Silva, A. M. G., Synthesis and coordination studies of 5-(4′-carboxyphenyl)-10,15,20-tris(pentafluorophenyl)porphyrin and its pyrrolidine-fused chlorin derivative, New J. Chem. 2018, 42, 8169-8179.

[5] Almeida, J., Aguiar, A., Leite, A., Silva, A.M.N., Cunha-Silva, L., de Castro, B., Rangel, M., Barone, G., Tomé, A.C., Silva, A.M.G., 1,3-Dipolar cycloadditions with meso-tetraarylchlorins – site selectivity and mixed bisadducts, Org. Chem. Front., 2017, 4, 534-544.