>Ana Margarida Silva

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Ana M. G. Silva received her PhD in Chemistry from UAveiro in 2002 and completed her graduation in Chemistry, Food Chemistry in 1997 at the same University. In 2003, she was awarded with an FCT post-doctoral fellowship (SFRH/BPD/8374/2002) at UAveiro, where she acquired a solid expertise in organic chemistry, particularly in porphyrin’s chemistry. During the PhD and Post-doc periods, she carried out 3 internships with research groups of: Prof A. Dondoni (UFerrara, Italy) and Prof O. Kappe (UGraz, Austria), where she learned advanced strategies to synthesise carbohydrate derivatives and developed various microwave protocols related to the porphyrins derivatization. Since 2007, she holds a researcher position (with different contractual levels) at REQUIMTE, UPorto. While maintaining interest in porphyrin chemistry, she started a new line of research dedicated to the synthesis, characterization and development of strong bright xanthene fluorophores using sustainable chemistry approaches, for applications in medicine and environment remediation. In 2015, she held a temporary position (4 months) as a NMR spectroscopy technician at CEMUP, UPorto, while simultaneously keeping active her scientific research commitments. AMGS merged her know-how in organic chemistry with her expertise in metal complexes to create new multifunctional ligands and luminescent materials for sensing applications and as a result in 2016 she was congratulated as a coordinator of the project M-ERA-NET/0005/2014.

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Area of scientific activity

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• Research interests in organic chemistry, particularly in the synthesis of porphyrinic macrocycles and xanthene derivatives;

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• Synthesis of 3-hydroxy-4-pyridinone and catechol ligands and their coordination complexes;

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• Synthesis of multifunctionalized molecules and fluorophores endowed with improved optical properties for application in medicine and the environment;

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• Fluorophore anchoring strategies in solid matrices for sensing applications;

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• Implementation of advanced synthetic methodologies based on the “green chemistry” concepts, including the use of microwave-assisted chemistry and the Ohmic heating using water as a solvent.

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Domain of specialization

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Chemical Synthesis, Sustainable Chemistry, Functional molecules, Photoactive Materials

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Membership​

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• Full membership of Sociedade Portuguesa de Química (SPQ) – since 1999

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• Full membership of Society of Porphyrins and Phthalocyanines (SPP) – since 2019

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• Full membership of Portuguese Association of Researchers and Students in the UK (Parsuk) - since 2022

 

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     >selected publications

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Moreira, M. I. F., Almeida, J., Leite, A., Lobo Ferreira, A. I. M. C., Santos, L. M. N. B. F., Silva, A. M. G.*, Rangel, M., “Ohmic heating-assisted synthesis and characterization of Zn(II), Cu(II) and Pd(II) complexes of heterocyclic–fused chlorins” Dalton Transactions, 2022, 51, 3520–3530. https://doi.org/10.1039/D1DT04032D. Selected as HOT Article.

 

Monteiro-Silva, F., Queirós, C., Leite, A., Teresa Rodríguez, M., José Rojo, M., Torroba, T., Martins R. C., Silva, A. M. G.*, Rangel M., “Synthesis of catechol derived rosamine dyes and their reactivity towards biogenic amines”, Molecules, 2021, 26, 5082. https://doi.org/10.3390/molecules26165082. This article belongs to the Special Issue Pigment, Dye, and Green Colorant Research in Europe.

 

Vargas, A. P., Almeida, J., Gámez, F., Roales, J., Queirós, C., Rangel, M., Lopes-Costa, T., Silva, A. M. G.*, Pedrosa, J. M.* “Synthesis of a highly emissive carboxylated pyrrolidine-fused chlorin for optical sensing of TATP vapours”, Dyes Pigm. 2021, 195, 109721. https://doi.org/10.1016/j.dyepig.2021.109721.

 

Almeida, J., Zhang, G., Wang, M., Queirós, C., Cerqueira, A. F. R., Tomé, A. C., Barone, G., Vicente, M. G. H., Hey-Hawkins, E., Silva, A. M. G.*, Rangel M. “Synthesis, characterization, and cellular investigations of porphyrin– and chlorin–indomethacin conjugates for photodynamic therapy of cancer” Org. Biomol. Chem. 2021, 19, 6501. https://doi.org/10.1039/d1ob01015h. Selected as Advance Article.

 

Sousaraei, A., Queirós, C., Moscoso, F. G., Silva, A. M. G., Lopes-Costa, T., Pedrosa, J. M., Cunha-Silva, L., Cabanillas-Gonzalez J. “Reversible Protonation of Porphyrinic Metal-Organic Frameworks Embedded in Nanoporous Polydimethylsiloxane for Colorimetric Sensing” Advanced Materials Interfaces 2021, 2001759. https://doi.org/10.1002/admi.202001759