PhD in Sustainable Chemistry in 2018, Faculty of Sciences, University of Porto; Faculty of Sciences and Technology, New University of Lisbon; University of Aveiro
Thesis: Fluorescent ligands and coordination polymers with potential application in metal ion sensing, photoluminescence and heterogeneous catalysis.
Area of scientific activity
Over the past 10 years several fields and projects have been developed, covering the areas of inorganic, organic and materials chemistry.
During my MSc. Project, the work focused on the study and characterization of fluoroquinolones and corresponding complexes in solution and their interaction with mimetic membrane systems, such as liposomes.
In the following years and under the scope of the project “New molecular architectures to fight infectious processes” (PTDC/QUI/67915/2006), the synthesis and photophysical characterization in solution of 3,4-hydroxypyridinones and catecholate derivatives was performed. The derivatives were based on several fluorophores (fluorescein, rhodamine and rosamine) and their application as metal ion sensors under physiological conditions was evaluated.
In the later years, during the PhD thesis and the development of the project “Gas optic sensors based on metal-organic frameworks - MOFsENS" (M-ERA-NET/0005/2014), the materials chemistry became the centre of the scientific research. The goals included the preparation and characterization and application as gas sensors of new materials based on fluorescent ligands and coordination polymers using isophthalate derivatives as ligands. The field of heterogeneous catalysis was also explored.
Nowadays, under the scope of “Xanthene-based optical sensors” project, with the reference PTDC/QUI-QOR/29426/2017, the work objectives are the design and application as optical sensors of xanthene-based materials, including coordination polymers and porphyrinic derivatives.
Domain of specialization
The domain of specialization is related with organic and inorganic chemistry fields, namely the design and characterization of new fluorescent molecules and coordination polymers with application as sensors and heterogenous catalysts.
The frequency of several courses and training schools, related with a COST action - COST CM 1302 - European network on Smart Inorganic Polymers - enabled the theoretical knowledge and hands-on skills in several techniques and fields, such as, NMR, EPR, mass spectrometry, powder and single crystal XRD. Specific practical and theoretical courses included: "Nuclear Magnetic Resonance Nuclear: from theory to practice" (2009, FCT-UNL), modern methods of structure elucidation (2012, in CQE-IST and IST/ITN), liposomes as nanodelivery systems (2011, FFUP) and fluorescence and related techniques applied to chemosensors and nanoparticles (2014, FCT-UNL).
Present research interest
In the current researcher position the work focus are xanthene-based compounds. The goals include the: i) synthesis of xanthene derivatives; ii) photophysical characterization in solution and solid state; iii) application as sensors (metal ions, gases and other compounds).
As a continuity of previous activities and the PhD work, several other interests prevail and embrace:
preparation, characterization of multifunctional coordination polymers;
design and application of coordination polymers as heterogeneous catalytic systems;
synthesis of functional building blocks, including porphyrinic derivatives, with potential application in environmental and medicinal fields.
The development of scientific knowledge and skills in the fields of solid state photophysical characterization and materials characterization using techniques as XRD, TGA, SEM and EPR.
Sousaraei, A., Queirós, C., Moscovo, F.G., Lopes-Costa, T., Pedrosa, J.M., Silva, A.M.G., Cunha-Silva, L., Cabanillas-Gonzalez, J. "Subppm Amine Detection via Absorption and Luminescence Turn-On Caused by Ligand Exchange in Metal Organic Frameworks" Anal. Chem. (2019) 91, 15853-15859 (doi: 10.1021/acs.analchem.9b04291)
Queirós, C., Leite, A., Cunha-Silva, L., de Castro B., Rangel, M., Sousaraei, A., Cabanillas-Gonzalez, J., Gámez, F., Jamardo, E., Vargas, A.P., Moscoso, F. G., Lopes-Costa, T., Pedrosa, J.M., Silva, A.M.G. “Synthesis and characterization of two fluorescent isophthalate rosamines: From solution to immobilization in solid substrates” Dyes Pigm. (2018) 154, 405-414 (doi: 10.1016/j.dyepig.2018.05.005).
Roales, J., Moscoso, F. G., Gámez, F., Lopes-Costa, T., Sousaraei, A., Casado, S., Castro-Smirnov, J.R., Cabanillas-Gonzalez, J., Almeida, J., Queirós, C., Cunha-Silva, L., Silva, A.M.G., Pedrosa, J.M. “Preparation of Luminescent Metal-Organic Framework Films by Soft-Imprinting for 2,4-Dinitrotoluene Sensing” Materials (2017) 10, 992, 12 pages (doi: 10.3390/ma10090992).
Queirós, C., Leite, A., Couto, M.G.M., Cunha-Silva, L., Barone, G., de Castro, B., Rangel, M., Silva, A.M.N., Silva, A.M.G. “The Influence of the Amide Linkage in the Fe(III)-Binding Properties of Catechol-Modified Rosamine Derivatives” Chem. Eur. J. (2015) 21, 15692-15704 (doi: 10.1002/chem.201502093).
Queirós, C., Silva, A.M.G., Lopes, S.C., Ivanova, G., Gameiro, P., Rangel, M. “A novel fluorescein-based dye containing a catechol chelating unit to sense iron(III)” Dyes Pigm. (2012) 93, 1447-1455 (doi: 10.1016/j.dyepig.2011.10.010).